Joint Seminars in Molecular Biology: "Structural identification of the RY12 domain of the RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene"

Oliver Clarke, Assistant Professor of Physiology and Cellular Biophysics (in Anesthesiology and the Irving Institute for Clinical and Translational Research), Columbia University, presents "Structural identification of the RY12 domain of the RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene".

Oliver Clarke is an Assistant Professor at Columbia University in the departments of Anesthesiology and Physiology. His laboratory employs structural and functional approaches to dissect complex molecular machines, with a particular focus on membrane proteins. Current research areas include the modulation of the ryanodine receptor by therapeutics and endogenous ligands, and the mechanism of ankyrin-mediated membrane protein clustering and its role in controlling cellular shape and membrane curvature.

Host: Jennifer Cash (jcash@ucdavis.edu)