Microbiology & Molecular Genetics

A DNA-Organizing Protein Offers New Insight into Infertility, IVF and Generational Health

The causes of male infertility can be hard to diagnose, with many tests failing to detect genetic defects. Sometimes, infertility doesn’t even involve the genes themselves. It can arise from improper folding of the father’s DNA in the sperm. If a couple conceives, this mispackaged DNA can damage the lifelong health of the child.

A Billion Daily Repairs: How Our Cells Mend Broken DNA

A major new discovery could inspire improved treatments for cancer and genetic diseases.

Coiled within our cells are fragile threads of DNA that contain the codes of life— determining when each of our 30 trillion cells must grow, divide, sit tight — or simply die. This arrangement is precarious. Billions of times per day, our DNA is severed by stray chemical reactions. Our cells must rebuild the broken DNA without making mistakes – or the consequences can be dire.

Landmark Discovery Reveals How Chromosomes Are Passed From One Generation to the Next

When a woman becomes pregnant, the outcome of that pregnancy depends on many things — including a crucial event that happened while she was still growing inside her own mother’s womb. It depends on the quality of the egg cells that were already forming inside her fetal ovaries. The DNA-containing chromosomes in those cells must be cut, spliced and sorted perfectly. In males, the same process produces sperm in the testes but occurs only after puberty.

Pancreatic Cancer Researcher Recognized for Excellence in Mentoring Undergraduate Researchers

In the college, undergraduate students don’t just learn from textbooks—they actively contribute to new scientific knowledge through hands-on research. This experiential learning is a hallmark of a UC Davis education, especially in the life sciences.

For his outstanding commitment to ensuring undergraduate students have these meaningful and immersive research experiences, Chang‑il Hwang, an associate professor of microbiology and molecular genetics, has received a 2025 Chancellor’s Award for Excellence in Mentoring Undergraduate Research.

Cell Biologist Elected as a Fellow of The Royal Society

Neil Hunter, a professor in the Department of Microbiology and Molecular Genetics and an Investigator with the Howard Hughes Medical Institute, has been elected as a Fellow of The Royal Society in London.

This prestigious appointment, announced May 20, was offered to only 70 scientists across the world.

“I’m thrilled and surprised,” said Hunter. “The acknowledgment means a great deal to me, because it’s an election by some of the best scientists in the world.”

3D Genome Structure Guides Sperm Development

A single set of genetic instructions produces thousands of structures in our bodies – from nerve cells that branch like gnarled oak trees, to osteoblast cells that sculpt minerals into bone. It begins with the delicate formation of sperm and eggs – which ignite the miraculous unfurling of an entire body from a single cell.

For this to happen, DNA must be precisely folded and coiled into the sperm and egg cells – creating a structure that coordinates thousands of genes, says Satoshi Namekawa, a professor of microbiology and molecular genetics.