Extramurally Funded Research

A DNA-Organizing Protein Offers New Insight into Infertility, IVF and Generational Health

The causes of male infertility can be hard to diagnose, with many tests failing to detect genetic defects. Sometimes, infertility doesn’t even involve the genes themselves. It can arise from improper folding of the father’s DNA in the sperm. If a couple conceives, this mispackaged DNA can damage the lifelong health of the child.

Training Naturalists Behind Prison Walls

A kestrel swoops to grab a smaller bird on the wing and eats it, right in front of a group of men in the garden at California Health Care Facility, or CHCF, a prison in Stockton, where the garden has become both a thriving ecosystem and a science classroom for people incarcerated there. As the feathers fly, UC Davis researcher Laci Gerhart pulls out a bird guide and shows the incarcerated men how to identify the bird by its size and coloration, noting that kestrels are North America’s smallest raptor and one of the few that are sexually dimorphic. 

This Single Mother Must Learn Quickly — Or Her Colony Won’t Survive

Being a single mother of 20 is no joke, especially if the survival of a whole species depends on it. 

A queen bumblebee faces this very challenge when she lays her first eggs in the spring: She is utterly alone, with no worker bees to help.

She flies miles each day, collecting nectar to feed her young. She builds a protective nursery from wax. When she’s not out foraging, she climbs atop her larvae and buzzes to warm them. 

A Fresh Approach to Peppermint

The genomics of peppermint are not as fresh as their flavor but scientists from the University of California, Davis, have found a way to breathe new genetic variation into the species.

A Baby Bird’s Wishlist: Mild Weather, Attentive Parents, Not Being the Smallest Sibling

Experiences in the first days and weeks of life can have a profound impact on humans — and birds. A new study led by Sage Madden, a graduate student working with Gail Patricelli, a professor of evolution and ecology, shows how weather conditions and family dynamics affect the growth of barn swallow (Hirundo rustica erythrogaster) chicks. 

Children with Rare, Debilitating Brain Diseases Suffer from Mutations in a Little-Known Protein Complex

Thousands of times per year, a family’s moment of joy turns to unexpected grief. A seemingly healthy infant stops smiling or making eye contact. Their limbs grow weak. The tiny child suffers seizures and breathing problems.

Jawdat Al-Bassam, an associate professor of molecular and cellular biology at the University of California, Davis, often hears from these families. “I’ve gotten emails from folks all over the world,” he said.

Plants Walk a Fine Line Between Growth and Defense

Salicylic acid, the active molecule in aspirin and some acne medications, is a hormone in plants that is essential for immunity, but it’s a double-edged sword: too much can cause autoimmunity and stunt growth. In a new study published April 20 in Nature Communications, University of California, Davis, researchers discovered that plants use a surprising multi-layered system to regulate salicylic acid levels and keep their immune system in check.

Fish Evolution Accelerated After Adapting to Eat off Hard Surfaces

Why are there so many species of coral reef fish? According to a new study, it’s because about 50 million years ago, some fish figured out how to bite food from hard surfaces. 

Evolution doesn’t proceed at an even pace—species evolve in jumps and spurts, followed by lulls. These periods of rapid diversification usually occur after a dramatic environmental change or upheaval, or when a lineage develops a new “innovation” that allows them to use a previously inaccessible resource. For fish, the ability to feed from a hard surface was one such innovation.

A Billion Daily Repairs: How Our Cells Mend Broken DNA

A major new discovery could inspire improved treatments for cancer and genetic diseases.

Coiled within our cells are fragile threads of DNA that contain the codes of life— determining when each of our 30 trillion cells must grow, divide, sit tight — or simply die. This arrangement is precarious. Billions of times per day, our DNA is severed by stray chemical reactions. Our cells must rebuild the broken DNA without making mistakes – or the consequences can be dire.