Fertility is finite for mammalian females. From birth, females possess a limited number of primordial follicles that are collectively called the ovarian reserve. Within each follicle is an oocyte that eventually becomes an egg. But with age, the viability of the ovarian reserve decreases.
“Despite its fundamental importance, our understanding how the ovarian reserve is established and maintained remains poor,” said UC Davis Professor Satoshi Namekawa, Department of Microbiology and Molecular Genetics.